The 2014 Estimated Treatment Costs are a weighted average of the different 2014 HCV treatment regimen costs using Express Scripts’ book of business distributions and genotype distributions from the literature. Future costs are estimated for 2015 and 2016 until more information is available. An annual compounded brand inflation rate of 5% was assumed for costs in 2015 and 2016. Regimen distributions may be adjusted if client specific distributions are known, which in turn, adjusts estimated treatment costs.